MRPS18–2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties

We report that the overexpression of mitochondrial ribosomal protein MRPS18–2 (S18–2) can immortalize primary rat embryonic fibroblasts (REFs). The immortalized cells (18IM) lose contact inhibition, form foci, and are capable of anchorage-independent growth. Concurrently, mesodermal markers, such as...

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Bibliografiske detaljer
Main Authors: Kashuba, Elena, Pavan Yenamandra, Surya, Deoram Darekar, Suhas, Yurchenko, Mariya, Kashuba, Vladimir, Klein, George, Szekely, Laszlo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785258/
https://ncbi.nlm.nih.gov/pubmed/19903879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911545106
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