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MRPS18–2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties
We report that the overexpression of mitochondrial ribosomal protein MRPS18–2 (S18–2) can immortalize primary rat embryonic fibroblasts (REFs). The immortalized cells (18IM) lose contact inhibition, form foci, and are capable of anchorage-independent growth. Concurrently, mesodermal markers, such as...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785258/ https://ncbi.nlm.nih.gov/pubmed/19903879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911545106 |
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