Epstein-Barr Virus Immortalization of Human B-Cells Leads to Stabilization of Hypoxia-Induced Factor 1 Alpha, Congruent with the Warburg Effect

BACKGROUND: Epstein-Barr virus (EBV) encodes six nuclear transformation-associated proteins that induce extensive changes in cellular gene expression and signaling and induce B-cell transformation. The role of HIF1A in EBV-induced B-cell immortalization has not been previously studied. METHODS AND F...

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Main Authors: Darekar, Suhas, Georgiou, Konstantinos, Yurchenko, Mariya, Yenamandra, Surya Pavan, Chachami, Georgia, Simos, George, Klein, George, Kashuba, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407085/
https://ncbi.nlm.nih.gov/pubmed/22848707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042072
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