Breast Cancer-derived Factors Stimulate Osteoclastogenesis through the Ca(2+)/Protein Kinase C and Transforming Growth Factor-β/MAPK Signaling Pathways

Breast cancer commonly metastasizes to bone where its growth depends on the action of bone-resorbing osteoclasts. We have previously shown that breast cancer cells secrete factors able to directly stimulate osteoclastogenesis from receptor activator of nuclear factor κB ligand (RANKL)-primed precurs...

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Detalhes bibliográficos
Main Authors: Tiedemann, Kerstin, Hussein, Osama, Sadvakassova, Gulzhakhan, Guo, Yubin, Siegel, Peter M., Komarova, Svetlana V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785208/
https://ncbi.nlm.nih.gov/pubmed/19801662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010785
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