Role of the Rad52 Amino-terminal DNA Binding Activity in DNA Strand Capture in Homologous Recombination

Saccharomyces cerevisiae Rad52 protein promotes homologous recombination by nucleating the Rad51 recombinase onto replication protein A-coated single-stranded DNA strands and also by directly annealing such strands. We show that the purified rad52-R70A mutant protein, with a compromised amino-termin...

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Bibliographic Details
Main Authors: Shi, Idina, Hallwyl, Swee C. L., Seong, Changhyun, Mortensen, Uffe, Rothstein, Rodney, Sung, Patrick
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785170/
https://ncbi.nlm.nih.gov/pubmed/19812039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057752
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