Procaspase 8 and Bax Are Up-regulated by Distinct Pathways in Streptococcal Pyrogenic Exotoxin B-induced Apoptosis

We have previously identified integrin α(v)β(3) and Fas as receptors for the streptococcal pyrogenic exotoxin B (SPE B), and G308S, a mutant of SPE B that binds to Fas only. In the current study we found that after binding to α(v)β(3), SPE B stimulated the tyrosine phosphorylation of JAK2 and STAT1....

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Autores principales: Chang, Chia-Wen, Tsai, Wan-Hua, Chuang, Woei-Jer, Lin, Yee-Shin, Wu, Jiunn-Jong, Liu, Ching-Chuan, Tsai, Pei-Jane, Lin, Ming T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785162/
https://ncbi.nlm.nih.gov/pubmed/19801665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.020586
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