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Solution phase synthesis of a diverse isocoumarin library

The solution phase synthesis of a 167-member library of isocoumarins is described. The key intermediates for library generation, 4-iodoisocoumarins, are easily prepared by iodocyclization of the corresponding 2-(1-alkynyl)arenecarboxylate esters. The 4-iodoisocoumarins undergo palladium-catalyzed So...

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Detalhes bibliográficos
Main Authors: Roy, Sujata, Roy, Sudipta, Neuenswander, Benjamin, Hill, David, Larock, Richard C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785110/
https://ncbi.nlm.nih.gov/pubmed/19817453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc9001197
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