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Solution phase synthesis of a diverse isocoumarin library
The solution phase synthesis of a 167-member library of isocoumarins is described. The key intermediates for library generation, 4-iodoisocoumarins, are easily prepared by iodocyclization of the corresponding 2-(1-alkynyl)arenecarboxylate esters. The 4-iodoisocoumarins undergo palladium-catalyzed So...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785110/ https://ncbi.nlm.nih.gov/pubmed/19817453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc9001197 |
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