Effectiveness of Donepezil, Rivastigmine, and (±)Huperzine A in Counteracting the Acute Toxicity of Organophosphorus Nerve Agents: Comparison with Galantamine

Galantamine, a centrally acting cholinesterase (ChE) inhibitor and a nicotinic allosteric potentiating ligand used to treat Alzheimer's disease, is an effective and safe antidote against poisoning with nerve agents, including soman. Here, the effectiveness of galantamine was compared with that...

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Autors principals: Aracava, Yasco, Pereira, Edna F. R., Akkerman, Miriam, Adler, Michael, Albuquerque, Edson X.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2009
Matèries:
Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784713/
https://ncbi.nlm.nih.gov/pubmed/19741148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160028
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