Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes

Earlier reports suggested that galantamine, a drug approved to treat mild-to-moderate Alzheimer’s disease (AD), and other centrally acting reversible acetylcholinesterase (AChE) inhibitors can serve as adjunct pretreatments against poisoning by organophosphorus compounds, including the nerve agent s...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Lane, Malcolm, Carter, D’Arice, Pescrille, Joseph D., Aracava, Yasco, Fawcett, William P., Basinger, G. William, Pereira, Edna F.R., Albuquerque, Edson X.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495338/
https://ncbi.nlm.nih.gov/pubmed/32759369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.265843
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