Enhanced Digestion Efficiency, Peptide Ionization Efficiency, and Sequence Resolution for Protein Hydrogen/Deuterium Exchange Monitored by FT-ICR Mass Spectrometry

Solution-phase hydrogen/deuterium exchange (HDX) monitored by high-resolution FT-ICR mass spectrometry offers a rapid method to study protein conformations and protein-protein interactions. Pepsin is usually used to digest proteins in HDX and is known as lack of cleavage specificity. To improve dige...

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Bibliografski detalji
Glavni autori: Zhang, Hui-Min, Kazazic, Saša, Schaub, Tanner M., Tipton, Jeremiah D., Emmett, Mark R., Marshall, Alan G.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784605/
https://ncbi.nlm.nih.gov/pubmed/19551977
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