Automated Data Reduction for Hydrogen/Deuterium Exchange Experiments, Enabled by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Mass analysis of proteolytic fragment peptides following hydrogen/deuterium exchange offers a general measure of solvent accessibility/hydrogen bonding (and thus conformation) of solution-phase proteins and their complexes. The primary problem in such mass analyses is reliable and rapid assignment o...

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Detalhes bibliográficos
Main Authors: Kazazic, Sasa, Zhang, Hui-Min, Schaub, Tanner M., Emmett, Mark R., Hendrickson, Christopher L., Blakney, Gregory T., Marshall, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901854/
https://ncbi.nlm.nih.gov/pubmed/20116280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2009.12.016
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