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Partial CD4 depletion reduces regulatory T cells induced by multiple vaccinations and restores therapeutic efficacy
PURPOSE: A single vaccination of intact or reconstituted-lymphopenic mice (RLM) with a GM-CSF-secreting B16BL6-D5 (D5-G6) melanoma cell line induces protective antitumor immunity and T cells that mediate regression of established melanoma in adoptive immunotherapy studies. We wanted to study if mult...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784281/ https://ncbi.nlm.nih.gov/pubmed/19903784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1113 |
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