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Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries
The cytochrome P450 (CYP) gene family strongly influences drug development. We determined potency values for 17,143 compounds against recombinant CYP 1A2, 2C9, 2C19, 2D6, and 3A4 enzymes through an in vitro bioluminescent assay. The compound collections included substances from typical libraries and...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783980/ https://ncbi.nlm.nih.gov/pubmed/19855396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1581 |
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