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Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries
The cytochrome P450 (CYP) gene family strongly influences drug development. We determined potency values for 17,143 compounds against recombinant CYP 1A2, 2C9, 2C19, 2D6, and 3A4 enzymes through an in vitro bioluminescent assay. The compound collections included substances from typical libraries and...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783980/ https://ncbi.nlm.nih.gov/pubmed/19855396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1581 |
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