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An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation

Inflammation is linked clinically and epidemiologically to cancer, and NF-κB appears to play a causative role, but the mechanisms are poorly understood. We show that transient activation of Src oncoprotein can mediate an epigenetic switch from immortalized breast cells to a stably transformed line t...

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Bibliografske podrobnosti
Main Authors: Iliopoulos, Dimitrios, Hirsch, Heather A., Struhl, Kevin
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783826/
https://ncbi.nlm.nih.gov/pubmed/19878981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.10.014
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