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AGT-181: Expression in CHO Cells and Pharmacokinetics, Safety, and Plasma Iduronidase Enzyme Activity in Rhesus Monkeys
Enzyme replacement therapy is not effective for the brain, owing to the lack of transport of the enzyme across the blood-brain barrier (BBB). Recombinant proteins such as the lysosomal enzyme, iduronidase, can penetrate the human BBB, following the re-engineering of the protein as an IgG fusion prot...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783776/ https://ncbi.nlm.nih.gov/pubmed/19735678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2009.08.019 |
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