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Indirect and Direct Detection of the 4-(Benzothiazol-2-yl) phenylnitrenium Ion from a Putative Metabolite of a Model Anti-Tumor Drug
[Image: see text] 2-(4-Aminophenyl)benzothiazoles related to 1 are potentially important pharmaceuticals. Metabolism apparently involves oxidation and esterification to 3. In water, hydrolysis and photolysis of 3 generates the nitrenium ion 4 that can be detected indirectly by N(3)(−) trapping and d...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783571/ https://ncbi.nlm.nih.gov/pubmed/19788283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol901959z |
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