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Indirect and Direct Detection of the 4-(Benzothiazol-2-yl) phenylnitrenium Ion from a Putative Metabolite of a Model Anti-Tumor Drug
[Image: see text] 2-(4-Aminophenyl)benzothiazoles related to 1 are potentially important pharmaceuticals. Metabolism apparently involves oxidation and esterification to 3. In water, hydrolysis and photolysis of 3 generates the nitrenium ion 4 that can be detected indirectly by N(3)(−) trapping and d...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783571/ https://ncbi.nlm.nih.gov/pubmed/19788283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol901959z |
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