Loading...
Chemistry of Ring-Substituted 4-(Benzothiazol-2-yl)phenylnitrenium Ions from Anti-Tumor 2-(4-Aminophenyl)benzothiazoles
Ring substituted derivatives of 2-(4-aminophenyl)benzothiazole, 1a, 1b–1g, are under development as anti-tumor agents. One derivative, 1f, has reached Phase 1 clinical trials as the pro-drug, 2f, Phortress (NSC 710305). These amines are activated by CYP450 1A1, apparently into hydroxylamines, 8a–8g,...
Na minha lista:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740366/ https://ncbi.nlm.nih.gov/pubmed/23786256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo400826f |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|