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Chemistry of Ring-Substituted 4-(Benzothiazol-2-yl)phenylnitrenium Ions from Anti-Tumor 2-(4-Aminophenyl)benzothiazoles
Ring substituted derivatives of 2-(4-aminophenyl)benzothiazole, 1a, 1b–1g, are under development as anti-tumor agents. One derivative, 1f, has reached Phase 1 clinical trials as the pro-drug, 2f, Phortress (NSC 710305). These amines are activated by CYP450 1A1, apparently into hydroxylamines, 8a–8g,...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740366/ https://ncbi.nlm.nih.gov/pubmed/23786256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo400826f |
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