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Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements
Close to 50 % of the human genome harbors repetitive sequences originally derived from mobile DNA elements, and in normal cells this sequence compartment is tightly regulated by epigenetic silencing mechanisms involving chromatin-mediated repression. In cancer cells, repetitive DNA elements suffer a...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783545/ https://ncbi.nlm.nih.gov/pubmed/19699787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2009.08.006 |
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