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Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements

Close to 50 % of the human genome harbors repetitive sequences originally derived from mobile DNA elements, and in normal cells this sequence compartment is tightly regulated by epigenetic silencing mechanisms involving chromatin-mediated repression. In cancer cells, repetitive DNA elements suffer a...

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Detalhes bibliográficos
Main Authors: Szpakowski, Sebastian, Sun, Xueguang, Lage, José M., Dyer, Andrew, Rubinstein, Jill, Kowalski, Diane, Sasaki, Clarence, Costa, Jose, Lizardi, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783545/
https://ncbi.nlm.nih.gov/pubmed/19699787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2009.08.006
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