Sequence-Specific Biosensors Report Drug-Induced Changes in Epigenetic Silencing in Living Cells

Treatment with demethylating drugs can induce demethylation and reactivation of abnormally silenced tumor suppressor genes in cancer cells, but it can also induce potentially deleterious loss of methylation of repetitive elements. To enable the observation of unwanted drug effects related to loss of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Xudong, Narayanaswamy, Rammohan, Fenn, Kathleen, Szpakowski, Sebastian, Sasaki, Clarence, Costa, Jose, Blancafort, Pilar, Lizardi, Paul M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2012
Pynciau:
Original Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460616/
https://ncbi.nlm.nih.gov/pubmed/22313050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2011.1537
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