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Sequence-Specific Biosensors Report Drug-Induced Changes in Epigenetic Silencing in Living Cells

Treatment with demethylating drugs can induce demethylation and reactivation of abnormally silenced tumor suppressor genes in cancer cells, but it can also induce potentially deleterious loss of methylation of repetitive elements. To enable the observation of unwanted drug effects related to loss of...

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Detaylı Bibliyografya
Asıl Yazarlar: Huang, Xudong, Narayanaswamy, Rammohan, Fenn, Kathleen, Szpakowski, Sebastian, Sasaki, Clarence, Costa, Jose, Blancafort, Pilar, Lizardi, Paul M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460616/
https://ncbi.nlm.nih.gov/pubmed/22313050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2011.1537
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