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Sequence-Specific Biosensors Report Drug-Induced Changes in Epigenetic Silencing in Living Cells
Treatment with demethylating drugs can induce demethylation and reactivation of abnormally silenced tumor suppressor genes in cancer cells, but it can also induce potentially deleterious loss of methylation of repetitive elements. To enable the observation of unwanted drug effects related to loss of...
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| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Mary Ann Liebert, Inc.
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460616/ https://ncbi.nlm.nih.gov/pubmed/22313050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2011.1537 |
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