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An Autoinhibited Coiled-Coil Design Strategy for Split-Protein Protease Sensors
Proteases are widely studied as they are integral players in cell cycle control and apoptosis. We report a new approach for the design of a family of genetically encoded turn-on protease biosensors. In our design, an auto-inhibited coiled-coil switch is turned on upon proteolytic cleavage, which res...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783329/ https://ncbi.nlm.nih.gov/pubmed/19803505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9050857 |
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