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6-s-cis Conformation and Polar Binding Pocket of the Retinal Chromophore in the Photoactivated State of Rhodopsin

The visual pigment rhodopsin is unique among the G protein-coupled receptors in having an 11-cis retinal chromophore covalently bound to the protein through a protonated Schiff base linkage. The chromophore locks the visual receptor in an inactive conformation through specific steric and electrostat...

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Autores principales: Ahuja, Shivani, Eilers, Markus, Hirshfeld, Amiram, Yan, Elsa C. Y., Ziliox, Martine, Sakmar, Thomas P., Sheves, Mordechai, Smith, Steven O.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783296/
https://ncbi.nlm.nih.gov/pubmed/19795853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9034768
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