Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in Human Mammary Epithelial Cells

Many cancers, including breast cancer, harbor loss of function mutations in the catalytic domain of the PTEN phosphatase or have reduced PTEN expression through loss of heterozygosity (LOH) and/or epigenetic silencing mechanisms. However, specific phenotypic effects of PTEN inactivation in human can...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Vitolo, Michele I., Weiss, Michele B., Szmacinski, Marta, Tahir, Khola, Waldman, Todd, Park, Ben Ho, Martin, Stuart S., Weber, David J., Bachman, Kurtis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783190/
https://ncbi.nlm.nih.gov/pubmed/19843859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1067
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky