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Asymmetric synthesis of (2S,3R)-(-)-epi-CP-99,994 using sulfinimine-derived anti-2,3-diamino esters

A differentially protected C-3 N-sulfinyl, C-2 N,N-(diphenylmethylene) 2,3-diamino ester was employed in the synthesis of the amino piperidine (2S,3R)-(-)-epi-CP-99,994. Key steps in the synthesis included the chemoselective hydrolysis of the C-2 N,N-(diphenylmethylene) group and its reprotection as...

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Detalhes bibliográficos
Main Authors: Davis, Franklin A., Zhang, Yanfeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782829/
https://ncbi.nlm.nih.gov/pubmed/20161386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.06.125
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