Stabilization of the Tertiary Structure of the Cholera Toxin A1 Subunit Inhibits Toxin Dislocation and Cellular Intoxication

Cholera toxin (CT) moves from the cell surface to the endoplasmic reticulum (ER) by retrograde vesicular transport. The catalytic subunit of CT (CTA1) then crosses the ER membrane and enters the cytosol in a process that involves the quality control mechanism of ER-associated degradation. The molecu...

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Détails bibliographiques
Auteurs principaux: Massey, Shane, Banerjee, Tuhina, Pande, Abhay H., Taylor, Michael, Tatulian, Suren A., Teter, Ken
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782630/
https://ncbi.nlm.nih.gov/pubmed/19748510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.09.013
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