Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity

The synthesis, biological testing and NMR studies of several analogues of H-c[Cys(3)-Phe(6)-Phe(7)-dTrp(8)-Lys(9)-Thr(10)-Phe(11)-Cys(14)]-OH (ODT-8, a pan-somatostatin analogue) (1), have been performed to assess the effect of changing the stereochemistry and the number of the atoms in the disulfid...

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Main Authors: Erchegyi, Judit, Grace, Christy Rani R., Samant, Manoj, Cescato, Renzo, Piccand, Veronique, Riek, Roland, Reubi, Jean Claude, Rivier, Jean E.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782568/
https://ncbi.nlm.nih.gov/pubmed/18410084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701444y
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