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The capacity of Group V sPLA(2) to increase atherogenicity of apoE(-/-) and LDLR(-/-) mouse LDL in vitro predicts its atherogenic role in vivo
OBJECTIVE: In vitro data indicate that human LDL modified by Group V secretory phospholipase A(2) (GV sPLA(2)) is pro-atherogenic. Consistent with this, gain and loss of function studies demonstrated that GV sPLA(2) promotes atherosclerosis in LDLR(-/-) mice. The current study investigates whether G...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782483/ https://ncbi.nlm.nih.gov/pubmed/19164803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.183038 |
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