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The capacity of Group V sPLA(2) to increase atherogenicity of apoE(-/-) and LDLR(-/-) mouse LDL in vitro predicts its atherogenic role in vivo

OBJECTIVE: In vitro data indicate that human LDL modified by Group V secretory phospholipase A(2) (GV sPLA(2)) is pro-atherogenic. Consistent with this, gain and loss of function studies demonstrated that GV sPLA(2) promotes atherosclerosis in LDLR(-/-) mice. The current study investigates whether G...

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Autors principals: Boyanovsky, Boris, Zack, Melissa, Forrest, Kathy, Webb, Nancy R.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782483/
https://ncbi.nlm.nih.gov/pubmed/19164803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.183038
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