Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

Accumulation of stochastic DNA damage throughout organisms’ lifespan is thought to contribute to aging. Conversely, aging appears phenotypically reproducible and regulated through genetic pathways such as the insulin-like growth factor-1 (IGF-1) and growth hormone (GH) receptors, which are central m...

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Detalhes bibliográficos
Main Authors: Garinis, George A., Uittenboogaard, Lieneke M., Stachelscheid, Heike, Fousteri, Maria, van Ijcken, Wilfred, Breit, Timo M., van Steeg, Harry, Mullenders, Leon H.F., van der Horst, Gijsbertus T.J., Brüning, Jens C., Niessen, Carien M., Hoeijmakers, Jan H.J., Schumacher, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782455/
https://ncbi.nlm.nih.gov/pubmed/19363488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1866
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