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Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

The core oscillator generating circadian rhythms in eukaryotes is composed of transcription–translation-based autoregulatory feedback loops in which clock gene products negatively affect their own expression. A key step in this mechanism involves the periodic nuclear accumulation of clock proteins f...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yagita, Kazuhiro, Tamanini, Filippo, Yasuda, Maya, Hoeijmakers, Jan H.J., van der Horst, Gijsbertus T.J., Okamura, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC125916/
https://ncbi.nlm.nih.gov/pubmed/11889036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.6.1301
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