Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/γ-secretase activity

L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis. It is feasible that L1-dependent signalling contributes to these effects. Howeve...

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Bibliografiske detaljer
Main Authors: Riedle, Svenja, Kiefel, Helena, Gast, Daniela, Bondong, Sandra, Wolterink, Silke, Gutwein, Paul, Altevogt, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782312/
https://ncbi.nlm.nih.gov/pubmed/19260824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081625
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