Synergistic Induction of Endothelin-1 by Tumor Necrosis Factor α and Interferon γ Is due to Enhanced NF-κB Binding and Histone Acetylation at Specific κB Sites

Endothelin-1 (ET-1) is a potent vasoconstrictor and co-mitogen for vascular smooth muscle and is implicated in pulmonary vascular remodeling and the development of pulmonary arterial hypertension. Vascular smooth muscle is an important source of ET-1. Here we demonstrate synergistic induction of pre...

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Bibliografiske detaljer
Main Authors: Wort, Stephen J., Ito, Misako, Chou, Pai-Chien, Mc Master, Shaun K., Badiger, Rekha, Jazrawi, Elen, de Souza, Patricia, Evans, Timothy W., Mitchell, Jane A., Pinhu, Liao, Ito, Kaz, Adcock, Ian M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Transcription, Chromatin, and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782023/
https://ncbi.nlm.nih.gov/pubmed/19592490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032524
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