Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases

The regulation of metabolism and growth must be tightly coupled to guarantee the efficient use of energy and anabolic substrates throughout the cell cycle. Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential cont...

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Main Authors: Yalcin, Abdullah, Clem, Brian F., Simmons, Alan, Lane, Andrew, Nelson, Kristin, Clem, Amy L., Brock, Erin, Siow, Deanna, Wattenberg, Binks, Telang, Sucheta, Chesney, Jason
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Metabolism and Bioenergetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782016/
https://ncbi.nlm.nih.gov/pubmed/19473963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016816
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