Cyclosporin A Decreases Apolipoprotein E Secretion from Human Macrophages via a Protein Phosphatase 2B-dependent and ATP-binding Cassette Transporter A1 (ABCA1)-independent Pathway

Cyclosporin A (CsA) is an immunosuppressant that inhibits protein phosphatase 2B (PP2B/calcineurin) and is associated with hyperlipidemia, decreased cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1), and increased risk of atherosclerosis. Apolipoprotein E (apoE) is an important regu...

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Detalhes bibliográficos
Main Authors: Kockx, Maaike, Guo, Dongni Lily, Traini, Mathew, Gaus, Katharina, Kay, Jason, Wimmer-Kleikamp, Sabine, Rentero, Carles, Burnett, John R., Le Goff, Wilfried, Van Eck, Miranda, Stow, Jennifer L., Jessup, Wendy, Kritharides, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782008/
https://ncbi.nlm.nih.gov/pubmed/19589783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032615
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