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Dissecting Activation of the PAK1 Kinase at Protrusions in Living Cells
The p21-activated kinase (PAK) 1 kinase, an effector of the Cdc42 and Rac1 GTPases, regulates cell protrusions and motility by controlling actin and adhesion dynamics. Its deregulation has been linked to human cancer. We show here that activation of PAK1 is necessary for protrusive activity during c...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782007/ https://ncbi.nlm.nih.gov/pubmed/19574218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015271 |
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