Sac3 Is an Insulin-regulated Phosphatidylinositol 3,5-Bisphosphate Phosphatase: GAIN IN INSULIN RESPONSIVENESS THROUGH Sac3 DOWN-REGULATION IN ADIPOCYTES

Insulin-regulated stimulation of glucose entry and mobilization of fat/muscle-specific glucose transporter GLUT4 onto the cell surface require the phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P(2)) pathway for optimal performance. The reduced insulin responsiveness observed under ablation of th...

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Hlavní autoři: Ikonomov, Ognian C., Sbrissa, Diego, Ijuin, Takeshi, Takenawa, Tadaomi, Shisheva, Assia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781990/
https://ncbi.nlm.nih.gov/pubmed/19578118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025361
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