The Tail of KdsC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE

The phosphatase KdsC cleaves 3-deoxy-d-manno-octulosonate 8-phosphate to generate a molecule of inorganic phosphate and Kdo. Kdo is an essential component of the lipopolysaccharide envelope in Gram-negative bacteria. Because lipopolysaccharide is an important determinant of bacterial resistance and...

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Detalhes bibliográficos
Main Authors: Biswas, Tapan, Yi, Li, Aggarwal, Parag, Wu, Jing, Rubin, John R., Stuckey, Jeanne A., Woodard, Ronald W., Tsodikov, Oleg V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781614/
https://ncbi.nlm.nih.gov/pubmed/19726684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.012278
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