Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus

Desmocollin (Dsc) 1–3 and desmoglein (Dsg) 1–4, transmembrane proteins of the cadherin family, form the adhesive core of desmosomes. Here we provide evidence that Dsc3 homo- and heterophilic trans-interaction is crucial for epidermal integrity. Single molecule atomic force microscopy (AFM) revealed...

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Bibliografische gegevens
Hoofdauteurs: Spindler, Volker, Heupel, Wolfgang-Moritz, Efthymiadis, Athina, Schmidt, Enno, Eming, Rüdiger, Rankl, Christian, Hinterdorfer, Peter, Müller, Thomas, Drenckhahn, Detlev, Waschke, Jens
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2009
Onderwerpen:
Membrane Transport, Structure, Function, and Biogenesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781610/
https://ncbi.nlm.nih.gov/pubmed/19717567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024810
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