Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus

Desmocollin (Dsc) 1–3 and desmoglein (Dsg) 1–4, transmembrane proteins of the cadherin family, form the adhesive core of desmosomes. Here we provide evidence that Dsc3 homo- and heterophilic trans-interaction is crucial for epidermal integrity. Single molecule atomic force microscopy (AFM) revealed...

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Main Authors: Spindler, Volker, Heupel, Wolfgang-Moritz, Efthymiadis, Athina, Schmidt, Enno, Eming, Rüdiger, Rankl, Christian, Hinterdorfer, Peter, Müller, Thomas, Drenckhahn, Detlev, Waschke, Jens
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781610/
https://ncbi.nlm.nih.gov/pubmed/19717567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024810
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