Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus

Pemphigus vulgaris (PV) autoantibodies directly inhibit desmoglein (Dsg) 3-mediated transinteraction. Because cellular signaling also seems to be required for PV pathogenesis, it is important to characterize the role of direct inhibition in pemphigus acantholysis to allow establishment of new therap...

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Bibliografiske detaljer
Main Authors: Heupel, Wolfgang-Moritz, Müller, Thomas, Efthymiadis, Athina, Schmidt, Enno, Drenckhahn, Detlev, Waschke, Jens
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659217/
https://ncbi.nlm.nih.gov/pubmed/19164289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808813200
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