Suppression of Long Chain Acyl-CoA Synthetase 3 Decreases Hepatic de Novo Fatty Acid Synthesis through Decreased Transcriptional Activity

Long chain acyl-CoA synthetases (ACSL) and fatty acid transport proteins (FATP) activate fatty acids to acyl-CoAs in the initial step of fatty acid metabolism. Numerous isoforms of ACSL and FATP exist with different tissue distribution patterns, intracellular locations, and substrate preferences, su...

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Bibliographic Details
Main Authors: Bu, So Young, Mashek, Mara T., Mashek, Douglas G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781602/
https://ncbi.nlm.nih.gov/pubmed/19737935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036665
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