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Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling

Triacylglycerol accumulation in insulin target tissues is associated with insulin resistance. Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis, display improved glucose tolerance and insulin sensitivity de...

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Autors principals: Kienesberger, Petra C., Lee, Daeho, Pulinilkunnil, Thomas, Brenner, Daniel S., Cai, Lingzhi, Magnes, Christoph, Koefeler, Harald C., Streith, Ingo E., Rechberger, Gerald N., Haemmerle, Guenter, Flier, Jeffrey S., Zechner, Rudolf, Kim, Young-Bum, Kershaw, Erin E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781577/
https://ncbi.nlm.nih.gov/pubmed/19723629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047787
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