Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling

Triacylglycerol accumulation in insulin target tissues is associated with insulin resistance. Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis, display improved glucose tolerance and insulin sensitivity de...

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Hauptverfasser: Kienesberger, Petra C., Lee, Daeho, Pulinilkunnil, Thomas, Brenner, Daniel S., Cai, Lingzhi, Magnes, Christoph, Koefeler, Harald C., Streith, Ingo E., Rechberger, Gerald N., Haemmerle, Guenter, Flier, Jeffrey S., Zechner, Rudolf, Kim, Young-Bum, Kershaw, Erin E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781577/
https://ncbi.nlm.nih.gov/pubmed/19723629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047787
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