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Effects of Stability on the Biological Function of p53
The core domain of the tumor suppressor p53 has low thermodynamic stability, and many oncogenic mutations cause it to denature rapidly at body temperature. We made a series of core domain mutants that are significantly less or more stable than wild type to investigate effects of stability on the tra...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781498/ https://ncbi.nlm.nih.gov/pubmed/19700401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033183 |
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