A Novel Signaling Pathway: FIBROBLAST NICOTINIC RECEPTOR α1 BINDS UROKINASE AND PROMOTES RENAL FIBROSIS

The nicotinic acetylcholine receptor α1 (nAChRα1) was investigated as a potential fibrogenic molecule in the kidney, given reports that it may be an alternative urokinase (urokinase plasminogen activator; uPA) receptor in addition to the classical receptor uPAR. In a mouse obstructive uropathy model...

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Detalhes bibliográficos
Main Authors: Zhang, Guoqiang, Kernan, Kelly A., Thomas, Alison, Collins, Sarah, Song, Yumei, Li, Ling, Zhu, Weizhong, LeBoeuf, Renee C., Eddy, Allison A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781451/
https://ncbi.nlm.nih.gov/pubmed/19690163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010249
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