Novel Regulatory Site within the TM3–4 Loop of Human Recombinant α3 Glycine Receptors Determines Channel Gating and Domain Structure

Glycine receptors are Cys loop ligand-gated ion channels that mediate fast inhibitory synaptic transmission in the mammalian central nervous system. The functionally distinct splice variants α3L and α3K of the human glycine receptor differ by a 15-amino acid insert within the long intracellular TM3–...

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Bibliografiske detaljer
Main Authors: Breitinger, Hans-Georg, Villmann, Carmen, Melzer, Nima, Rennert, Janine, Breitinger, Ulrike, Schwarzinger, Stephan, Becker, Cord-Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Membrane Transport, Structure, Function, and Biogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781406/
https://ncbi.nlm.nih.gov/pubmed/19661067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043174
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