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Proinsulin C-peptide reduces diabetes-induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption

C-peptide reduces diabetes-induced glomerular hyperfiltration in diabetic patients and experimental animal models. However, the mechanisms mediating the beneficial effect of C-peptide remain unclear. We investigated whether altered renal afferent-efferent arteriole tonus or alterations in tubular Na...

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Main Authors: Nordquist, Lina, Brown, Russell, Fasching, Angelica, Persson, Patrik, Palm, Fredrik
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781335/
https://ncbi.nlm.nih.gov/pubmed/19741019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00228.2009
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