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Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes

The cellular kinase complex P-TEFb is composed of Cdk9 and cyclin T, and it is required for expression of most protein-coding genes by RNAP II. Cdk9 has been shown recently to be activated in cis by autophosphorylation of Thr186 in its T-loop. Using a phosphospecific Cdk9 antibody, we examined the l...

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Autors principals: Ramakrishnan, Rajesh, Dow, Eugene C., Rice, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: The Society for Leukocyte Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780919/
https://ncbi.nlm.nih.gov/pubmed/19741158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0509309
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