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Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop
Cdk9 is the catalytic subunit of a general RNA polymerase II elongation factor known as positive transcription elongation factor b (P-TEFb). The kinase function of P-TEFb requires phosphorylation of Thr-186 in the T-loop of Cdk9 to allow substrates to access the catalytic core of the enzyme. To iden...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586277/ https://ncbi.nlm.nih.gov/pubmed/18829461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807495200 |
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