Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

Cdk9 is the catalytic subunit of a general RNA polymerase II elongation factor known as positive transcription elongation factor b (P-TEFb). The kinase function of P-TEFb requires phosphorylation of Thr-186 in the T-loop of Cdk9 to allow substrates to access the catalytic core of the enzyme. To iden...

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Hlavní autoři: Wang, Yan, Dow, Eugene C., Liang, Yao-Yun, Ramakrishnan, Rajesh, Liu, Hongbing, Sung, Tzu-Ling, Lin, Xia, Rice, Andrew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Transcription, Chromatin, and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586277/
https://ncbi.nlm.nih.gov/pubmed/18829461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807495200
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