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Endoplasmic Reticulum Stress in Diabetic Hearts Abolishes Erythropoietin-Induced Myocardial Protection by Impairment of Phospho–Glycogen Synthase Kinase-3β–Mediated Suppression of Mitochondrial Permeability Transition

OBJECTIVE: Alteration in endoplasmic reticulum (ER) stress in diabetic hearts and its effect on cytoprotective signaling are unclear. Here, we examine the hypothesis that ER stress in diabetic hearts impairs phospho–glycogen synthase kinase (GSK)-3β–mediated suppression of mitochondrial permeability...

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Detalhes bibliográficos
Main Authors: Miki, Takayuki, Miura, Tetsuji, Hotta, Hiroyuki, Tanno, Masaya, Yano, Toshiyuki, Sato, Takahiro, Terashima, Yoshiaki, Takada, Akifumi, Ishikawa, Satoko, Shimamoto, Kazuaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780889/
https://ncbi.nlm.nih.gov/pubmed/19755525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0158
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